[Ala11,D-Leu15]-Orexin B

£125.00 1mg

Potent and selective orexin2 receptor agonist.

[Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist with 400-fold selectivity for OX2 over OX1 receptors, possessing EC50 values of 0.13 and 52 nM for human OX2 and OX1 receptors respectively. [Ala11,D-Leu15]-Orexin B increases social novelty seeking and can decrease anxious and depressive behaviour in animal models.

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SKU: OX-040 Categories: ,

Additional information

Other Names

[Ala(11), D-Leu(15)]orexin-B, [Ala11, d-Leu15] “OrxB

Three Letter Sequence

H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Molecular Weight

2857.28

Molecular Formula

C189H284N54O56S

Sequence

RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2

Solubility

Soluble to 0.30 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Modifications

C-terminal amide

Searchable Words

[Ala11,D-Leu15]-Orexin B, 532932-99-3, RSGPPGLQGRAQRLLQASGNHAAGILTM, RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2, [Ala(11), D-Leu(15)]orexin-B, OX-040, OX040