[Ala11,D-Leu15]-Orexin B
£125.00 1mg
Potent and selective orexin2 receptor agonist.
[Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist with 400-fold selectivity for OX2 over OX1 receptors, possessing EC50 values of 0.13 and 52 nM for human OX2 and OX1 receptors respectively. [Ala11,D-Leu15]-Orexin B increases social novelty seeking and can decrease anxious and depressive behaviour in animal models.
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Additional information
| Other Names | [Ala(11), D-Leu(15)]orexin-B, [Ala11, d-Leu15] “OrxB |
|---|---|
| Three Letter Sequence | H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2 |
| Molecular Weight | 2857.28 |
| Molecular Formula | C189H284N54O56S |
| Sequence | RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2 |
| Solubility | Soluble to 0.30 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Modifications | C-terminal amide |
| Searchable Words | [Ala11,D-Leu15]-Orexin B, 532932-99-3, RSGPPGLQGRAQRLLQASGNHAAGILTM, RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2, [Ala(11), D-Leu(15)]orexin-B, OX-040, OX040 |