Ac-DEVD-AMC

£49.00 1mg

Fluorogenic substrate for caspase-3.

Ac-DEVD-AMC is a fluorogenic substrate for caspase-3 with a Km value of 9.7 1.0 μM. The sequence of Ac-DEVD-AMC is based on the PARP cleavage site Asp216 for caspase-3 and it is also a substrate for caspases -1, -4, -7 and -8. Ac-DEVD-AMC can be used to monitor intracellular caspase activity with cleaved AMC moieties, reflecting caspase activity, being detected by fluorescence.

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SKU: PI-260 Categories: ,

Additional information

Three Letter Sequence

Ac-Asp-Glu-Val-Asp-AMC

Molecular Weight

675.7

Molecular Formula

C30H37N5O13

Sequence

DEVD

Solubility

Soluble in DMSO; dilute with buffer for use

Appearance

Lyophilised solid

Storage

We recommend storage desiccated, frozen and in the dark

Purity

‰¥97% (HPLC)

Modifications

Acetyl at N terminal, 7-amino-4-methylcoumarin (AMC) at C terminal

Searchable Words

DEVD, substrate, caspase-3 , 169332-61-0, Ac-DEVD-AMC, PI-260, PI260