Selective amylin antagonist.

AC 187 is an orally active, amylin receptor antagonist with an IC50 of 0.48 nM that displays 38 and 400 fold selectivity over calcitonin and CGRP receptors respectively. Blockade of amylin with AC 187 increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia. AC 187 alone increases feeding when infused into the area postrema.