AC 187

£175.00 1mg

Selective amylin antagonist.

AC 187 is an orally active, amylin receptor antagonist with an IC50 of 0.48 nM that displays 38 and 400 fold selectivity over calcitonin and CGRP receptors respectively. Blockade of amylin with AC 187 increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia. AC 187 alone increases feeding when infused into the area postrema.

SKU: CG-060 Categories: ,

Additional information

Three Letter Sequence

Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2

Molecular Weight

2890.25

Molecular Formula

C127H205N37O40

Sequence

Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by hplc

Modifications

N-terminal Ac, C-terminal amide

Searchable Words

AC 187, 151804-77-2, Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2, CG-060, CG060, CG 060