10Panx

£75.00 1mg

Blocks pannexin-1 gap junctions.

10Panx mimics a sequence (WRQAAFVDSY) in the second extracellular loop of Panx1 and is a panx-1 mimetic inhibitory peptide that blocks pannexin 1 gap junctions. 10Panx can inhibit Panx1 hemichannel mediated ATP release and inflammasome activation in astrocytes and macrophages and in vivo, pharmacological blockade of Panx1 hemichannels with 10Panx peptide attenuates the progression of acetaminophen induced hepatotoxicity, neuropathic pain and epilepsy.

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SKU: GJ-030 Categories: ,

Additional information

Other Names

Panx-1 mimetic inhibitory peptide, 10Panx1

Three Letter Sequence

H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH

Molecular Weight

1242.37

Molecular Formula

C58H79N15O16

Sequence

WRQAAFVDSY

Solubility

Soluble to 1 mg/ml in water

Appearance

Freeze dried solid

Storage

Store dry, frozen and in the dark

Purity

>95% by HPLC

Searchable Words

Panx-1 mimetic inhibitory peptide, 955091-53-9, 10Panx, WRQAAFVDSY, 10Panx1, GJ-030