10Panx
£75.00 1mg
Blocks pannexin-1 gap junctions.
10Panx mimics a sequence (WRQAAFVDSY) in the second extracellular loop of Panx1 and is a panx-1 mimetic inhibitory peptide that blocks pannexin 1 gap junctions. 10Panx can inhibit Panx1 hemichannel mediated ATP release and inflammasome activation in astrocytes and macrophages and in vivo, pharmacological blockade of Panx1 hemichannels with 10Panx peptide attenuates the progression of acetaminophen induced hepatotoxicity, neuropathic pain and epilepsy.
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Additional information
| Other Names | Panx-1 mimetic inhibitory peptide, 10Panx1 |
|---|---|
| Three Letter Sequence | H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH |
| Molecular Weight | 1242.37 |
| Molecular Formula | C58H79N15O16 |
| Sequence | WRQAAFVDSY |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| Purity | >95% by HPLC |
| Searchable Words | Panx-1 mimetic inhibitory peptide, 955091-53-9, 10Panx, WRQAAFVDSY, 10Panx1, GJ-030 |